Synthesis of 5-Chlorobenzotriazole Derivatives by Ultrasonic-microwave Radiation / 中国药师

ABSTRACT

Objective: To synthesize new desired 5-chlorobenzotriazole derivatives by ultrasonic-microwave radiation and perform structural characterization. Methods:5-Chlorobenzotriazole was used as the starting material and reacted with chloroacetonitrile to obtain the intermediate product, and then respectively reacted with 6-chloro nicotinaldehyde and 5-formaldehude-2-methoxy-pyridine to obtain corresponding target compounds. Results: Six desired 5-chlorobenzotriazole compounds have been synthesized and their structures were confirmed by melting point, IR, LC-MS and 1 H-NMR. Conclusion:Six desired 5-chlorobenzotriazole compounds are synthesized by ul-trasonic-microwave radiation.