Distribution and Drug-resistance of Pathogens of Nosocomial Infection in Spinal Cord Injury：395 Cases Re-port / 中国康复理论与实践

ABSTRACT

Objective To pave the way for clinical therapy and reasonable administration of antibiotics, and to analyze the kinds and drug-resistance of pathogens of nosocomial infection in patients with spinal cord injury. Methods Bacteriology of infection and drug resis-tance were analyzed in 395 patients with spinal cord injury in the hospital from Jun., 2012 to Dec., 2013. Results There were 132 cases with nosocomial infection. Most of the infections were found in urinary tract (71.1%) and lower respiratory tract (24.2%). The main pathogenic germs were Escherichia coli (45.6%), P. Aeruginosa (18.1%), K. pneumonia (11.4%) and P. mirabilis(8.7%), which were resistant to the sec-ond or third generation cephalosporins and quinolones moderately or severely, but sensitive toβ-lactamase inhibitor combinations and ami-noglycosides. Conclusion The main pathogenic bacteria in nosocomial infection of patients with spinal cord injury are G-bacilli. The bacte-ria are resistant moderately or severely to antibiotics, which should be selected rationally by bacterial culture and drug susceptibility test, and optimized rationally with PK/PD (pharmacokinetics and pharmacodynamics).