Expression of interleukin-17 in the periodontal tissue of alveolar resorption-induced periodontitis rats / 中国组织工程研究

ABSTRACT

BACKGROUND:Studies have found that interleukin-17 secreted from T helper cel s 17 has a high expression in the serum and injured tissues of periodontitis patients, but the specific relationship is stil unclear. Therefore, an appropriate animal model is necessary to analyze the expression of interleukin-17 in model rats. OBJECTIVE:To analyze the expression of interleukin-17 secreted from T helper cel s 17 in experimental periodontitis rat. METHODS:Rats were divided into three groupsthe chronic periodontitis model in ligation group was established by ligaturing the first molar on the left maxil ary, and rats were kil ed 8 weeks later;the alveolar resorption model in lipopolysaccharide group was established by injecting lipopolysaccharide, and rats were anesthetized and kil ed 20 days after the model was completed;rats in control group did not receive any disposal. RESULTS AND CONCLUSION:Under light microscope, the number of osteoclasts in the ligation group and lipopolysaccharide group was significantly higher than that in the control group (P0.05). These findings indicate that interleukin-17 exerts an important role in the alveolar resorption, and T helper cel s 17 may be involved in the local periodontal inflammation but have weak effects on the system inflammation.