Experimental research ofHaizao-Xiangsheng mixture in the treatment of chronic pharyngitis / 国际中医中药杂志

ABSTRACT

ObjectiveTo observe the effect ofHaizao-Xiangsheng mixture on signs and symptoms, blood index and tissue pathology of rabbit models with chronic pharyngitis.Methods60 Japanese white rabbits by random grouping method were divided into normal control group, model group, positive control group andHaizao- Xiangsheng mixture with high, medium and low dose group, with 10 rats in each group. Except the normal control group, rabbits in other groups were performed spraying ammonia in pharyngeal portion and submucosal injection of turpentine oil preparation to create chronic pharyngitis models. TheHaizao- Xiangsheng mixture, high, medium and low dose group were treated withHaizao-Xiangsheng mixture of 42, 21, 10.5 g/kg, the positive control group was treated with watermelon frost Runhou tablet suspension 5.04 g/kg, the normal control group and model group were treated with the same volume of saline. Animal signs and symptoms were recorded daily (including general conditions and temperature). After continuous administration of 7 days, red blood cell count (RBC), white blood cell count (WBC), percentage of neutrophils (N%), the percentage of mononuclear cells (M%) and percentage of lymphocytes (L%) were detected to observe the histological change of pharyngeal mucosa and lower tissue pathology.ResultsAfter administration, compared with the model group, high dose group ofHaizao-Xiangsheng mixture rabbit body temperature dropped (38.90 ± 0.21℃ vs. 39.23 ± 0.39℃,P< 0.05), WBC (10.1 ×1012/L ± 1.73 ×1012/Lvs. 13.1 ×1012/L ± 1.69 ×1012/L) decreased, and RBC increased (5.73 ×109/L ± 0.59 ×109/Lvs.5.19 ×109/L ± 0.43 ×109/L,P<0.01).ConclusionsHaizao-Xiangsheng mixture can improve signs and symptoms, hematology indexes and histopathological changes of the experimental rabbit models of chronic pharyngitis.