Expression and significance of NF-κB and MCP-1 in endometrial carcinoma / 重庆医学

ABSTRACT

Objective To detect the expression of NF‐κB ,MCP‐1 in the endometrial carcinoma and their significance .Methods The expression of NF‐κB ,MCP‐1 in 52 cases of patients with endometrial carcinoma selected from January 2003 to December 2013 , and in 16 cases of endometrial atypical hyperplasia and 19 cases of proliferative endometrial were detected by immunohistochemistry assay .The relationship and correlation between clinical pathological characteristics was analyzed .Results The expressions of NF‐κB ,MCP‐1 proteins were significantly higher in the endometrial carcinoma than those of the endometrial atypical hyperplasia and proliferative endometrial (P0 .05) .The expressions of these two proteins were positively correlated(r=0 .895 ,P<0 .05) .Conclusion NF‐κB ,MCP‐1 may participate in the progress of endometrial carcino‐ma .