Effects of Heat Preconditioning on Expression of Protein Kinase C in Myocardium of Rats after Overload Exercise / 中国康复理论与实践

ABSTRACT

Objective To investigate the effects of heat preconditioning (HP) on the expression of protein kinase C (PKC)δand PKCεin the myocardium of overload exercise rats. Methods 25 male three-month-old Sprague-Dauley rats were divided into control group (n=5), exercise group (n=10) and HP group (n=10). The expression of PKCδand PKCεin the myocardium was detected with immunohistochemis-try, real-time PCR and Western blotting 8 weeks after overload exercise. Results The expression of PKCδsignificantly increased in the exer-cise group compared with the control group and the HP group (P0.05). Conclusion PKCs may play an important role in the HP-induced cardio-protec-tion during overload exercise.