Difference expression of Cx37 and Cx40 of arteries in spontaneously hypertensive rats / 重庆医学
Chongqing Medicine
;
(36): 4-6, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-462809
ABSTRACT
Objective To investigate the change of connexin (Cx) in mesenteric artery (MA) and aorta of spontaneously hyper‐tensive rats (SHR) and normotensive rats .Methods Quantitative RT‐PCR and Werstern blot technique were used to compare the difference in the expression of Cx37 and Cx40 mRNA and protein in MA and aorta of SHR and normotensive rats .Results The level of Cx37 mRNA expression in MA from SHR was decreased compared with that of the normotensive rats (P0 .05) .The expression of Cx37 protein in MA from SHR was decreased compared with that of the normotensive rats (P0 .05) . Conclusion Hypertension may could decrease gap junctional communication in cells of MA and aorta from SHR by the downregu‐lation of the expression of Cx37 and/or Cx40 .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chongqing Medicine
Year:
2015
Type:
Article
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