Expression of vascular endothelial growth factor in condylar cartilage of rat models of functional mandibular deviation in puberty / 中国组织工程研究

ABSTRACT

BACKGROUND:Whether the functional mandibular deviation wil cause osteal mandibular deviation and whether the mandibular growth pattern wil change are stil controversial. Vascular endothelial growth factor can increase the endothelial permeability, stimulate endothelial cel mitosis and promote angiogenesis and regulate the formation of bone. OBJECTIVE:To investigate the effect of functional mandibular deviation on the expression levels of vascular endothelial growth factor in condylar cartilage in growing rats. METHODS:Sixty four-week-old male Sprague-Dawley rats were randomly divided into control group (n=20) and experimental group (n=40). Each animal in experimental group received a nichrome appliance which was designed by our team. Lower mandible suffered from left functional deviation (2.1±0.3) mm to simulate functional mandibular asymmetry. RESULTS AND CONCLUSION:The number of vascular endothelial growth factor-positive cels in the sagittal posterior deviation region of rats with functional mandibular deviation was less than that in the non-deviation region at 7-28 days after model establishment. The number of vascular endothelial growth factor-positive cels was less in the sagittal central and coronal central deviation region than in the non-deviation region in rats with functional mandibular deviation at 14-28 days after model establishment, but was close to the control group. The number of vascular endothelial growth factor-positive cels was less in the coronal lateral deviation region than in the non-deviation region and control group in rats with functional mandibular deviation at 14-28 days after model establishment. These results indicated that after the mandible functional lateral deviation in adolescent rats, the expression of vascular endothelial growth factor was different in bilateral condylar cartilage, caused the alterations in osteoblast activity in cartilage, and possibly affected the normal growth and development of rat mandible, suggesting that functional mandibular deviation should be corrected as early as possible.