Silver sulfadiazine water gel dressings for treating small skin defects combined with wound infection: an evaluation of biocompatibility / 中国组织工程研究

ABSTRACT

BACKGROUND:Silver sulfadiazine water gel dressings are a combination of two antibacterial drugs, which can play a local broad-spectrum, potent, long-lasting antibacterial effect to effectively control and prevent wound infection. OBJECTIVE:To observe the clinical efficacy of silver sulfadiazine water gel dressings on skin defects with wound infection and to explore its biocompatibility. METHODS:Thirty patients with skin defects combined with wound infection were randomized into observation and control groups. Folowing conventional debridement and dressing, the observation group was subject to wound rinse with normal saline, silver sulfadiazine water gel dressings and gauze bandage; in the control group, Vaseline gauze was used folowed by gauze bandage. Visual analog scale scores, dressing adhesion to wound, wound healing rate, and healing time were observed in the two groups at 0, 1, 2 weeks after dressing. RESULTS AND CONCLUSION:The visual analog scale scores in the observation group were significantly lower than those in the control group at 1 and 2 weeks after dressing (P < 0.01), and the wound healing rate was also higher in the observation group than the control group (P < 0.05); wound adhesions were milder in the observation group than the control group when dressing; the healing time was significantly shorter in the observation group than the control group (P < 0.05). These findings suggest that the silver sulfadiazine water gel dressing has good effects on the treatment of skin defects with wound infection, which can reduce pain, effectively control wound infections and promote wound healing.