Antimicrobial susceptibility of 9 strains of carbapenemase-producing Klebsiella pneumoniae / 中国感染与化疗杂志
Chinese Journal of Infection and Chemotherapy
; (6): 257-259, 2015.
Article
in Zh
| WPRIM
| ID: wpr-463168
Responsible library:
WPRO
ABSTRACT
Objective To analyze the resistant profile and genotypes ,as well as susceptibility to tigecycline in carbapenemase‐producing K lebsiella pneumoniae for better clinical management of such infections .Methods Nine strains of carbapenemase‐producing K .pneumoniae were isolated from clinical specimens during the period from February 2012 to May 2013 in our hospital .Bacterial identification and antimicrobial susceptibility testing were carried out with VITEK 2 Compact automatic microbiological assay systems .The phenotype of carbapenemase‐producing K . pneumoniae was detected by modified Hodges test .The genotype of carbapenemase was identified by PCR method .The susceptibility to tigecycline was tested by E‐test . Results All the 9 strains of carbapenemase‐producing K . pneumoniae were resistant to the 19 antibiotics tested .Modified Hodges test was positive for 7 strains (77 .8% ) .Target band of carbapenemase gene was identified in all the 9 strains of K . pneumoniae ,and all were confirmed as KPC‐2 gene .All the 9 strains were susceptible to tigecycline .Conclusions The resistance of carbapenemase‐producing K .pneumoniae is still serious .Tigecycline has shown good in vitro activity against such strains .
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Infection and Chemotherapy
Year:
2015
Type:
Article