Insights into granulosa cell tumors using spontaneous or genetically engineered mouse models / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 1-8, 2016.
Article
in English
| WPRIM
| ID: wpr-46321
ABSTRACT
Granulosa cell tumors (GCTs) are rare sex cord-stromal tumors that have been studied for decades. However, their infrequency has delayed efforts to research their etiology. Recently, mutations in human GCTs have been discovered, which has led to further research aimed at determining the molecular mechanisms underlying the disease. Mouse models have been important tools for studying GCTs, and have provided means to develop and improve diagnostics and therapeutics. Thus far, several genetically modified mouse models, along with one spontaneous mouse model, have been reported. This review summarizes the phenotypes of these mouse models and their applicability in elucidating the mechanisms of granulosa cell tumor development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Sex Cord-Gonadal Stromal Tumors
/
Models, Animal
/
Granulosa Cell Tumor
/
Granulosa Cells
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Clinical and Experimental Reproductive Medicine
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS