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The serum vitamin D level is inversely correlated with nonalcoholic fatty liver disease
Clinical and Molecular Hepatology ; : 146-151, 2016.
Article in English | WPRIM | ID: wpr-46330
ABSTRACT
BACKGROUND/

AIMS:

A low vitamin D level has been associated with metabolic syndrome and diabetes. However, an association between a low vitamin D level and nonalcoholic fatty liver disease (NAFLD) has not yet been definitively established. This study aimed to characterize the relationship between a vitamin D level and NAFLD in Korea.

METHODS:

A cross-sectional study involving 6,055 health check-up subjects was conducted. NAFLD was diagnosed on the basis of typical ultrasonographic findings and a history of alcohol consumption.

RESULTS:

The subjects were aged 51.7±10.3 years (mean±SD) and 54.7% were female. NAFLD showed a significant inverse correlation with the vitamin D level after adjusting for age and sex [odds ratio (OR)=0.85, 95% confidence interval (CI)=0.75-0.96]. The age- and sex-adjusted prevalence of NAFLD decreased steadily with increasing vitamin D level [OR=0.74, 95% CI=0.60-0.90, lowest quintile (≤14.4 ng/mL) vs highest quintile (≥28.9 ng/mL), p for trend 20 ng/mL) [OR=0.86, 95% CI=0.75-0.99] and the quintiles of the vitamin D level in a dose-dependent manner (p for trend=0.001).

CONCLUSIONS:

The serum level of vitamin D, even when within the normal range, was found to be inversely correlated with NAFLD in a dose-dependent manner. Vitamin D was found to be inversely correlated with NAFLD independent of known metabolic risk factors. These findings suggest that vitamin D exerts protective effects against NAFLD.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Vitamin D / Odds Ratio / Cross-Sectional Studies / Multivariate Analysis / Regression Analysis / Ultrasonography / Non-alcoholic Fatty Liver Disease Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Clinical and Molecular Hepatology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vitamin D / Odds Ratio / Cross-Sectional Studies / Multivariate Analysis / Regression Analysis / Ultrasonography / Non-alcoholic Fatty Liver Disease Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Clinical and Molecular Hepatology Year: 2016 Type: Article