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Magnetization-tagged MRI is a simple method for predicting liver fibrosis
Clinical and Molecular Hepatology ; : 140-145, 2016.
Article in English | WPRIM | ID: wpr-46331
ABSTRACT
BACKGROUND/

AIMS:

To assess the usefulness of magnetization-tagged magnetic resonance imaging (MRI) in quantifying cardiac-induced liver motion and deformation in order to predict liver fibrosis.

METHODS:

This retrospective study included 85 patients who underwent liver MRI including magnetization-tagged sequences from April 2010 to August 2010. Tagged images were acquired in three coronal and three sagittal planes encompassing both the liver and heart. A Gabor filter bank was used to measure the maximum value of displacement (MaxDisp) and the maximum and minimum values of principal strains (MaxP1 and MinP2, respectively). Patients were divided into three groups (no fibrosis, mild-to-moderate fibrosis, and significant fibrosis) based on their aspartate-aminotransferase-to-platelet ratio index (APRI) score. Group comparisons were made using ANOVA tests.

RESULTS:

The patients were divided into three groups according to APRI scores no fibrosis (≤0.5; n=41), moderate fibrosis (0.5-1.5; n=23), and significant fibrosis (>1.5; n=21). The values of MaxDisp were 2.9±0.9 (mean±SD), 2.3±0.7, and 2.1±0.6 in the no fibrosis, moderate fibrosis, and significant fibrosis groups, respectively (P<0.001); the corresponding values of MaxP1 were 0.05±0.2, 0.04±0.02, and 0.03±0.01, respectively (P=0.002), while those of MinP2 were -0.07±0.02, -0.05±0.02, and -0.04±0.01, respectively (P<0.001).

CONCLUSIONS:

Tagged MRI to quantify cardiac-induced liver motion can be easily incorporated in routine liver MRI and may represent a helpful complementary tool in the diagnosis of early liver fibrosis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Aspartate Aminotransferases / Severity of Illness Index / Blood Platelets / Magnetic Resonance Imaging / Retrospective Studies / Liver Cirrhosis Type of study: Observational study / Prognostic study Limits: Aged / Humans / Male Language: English Journal: Clinical and Molecular Hepatology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Aspartate Aminotransferases / Severity of Illness Index / Blood Platelets / Magnetic Resonance Imaging / Retrospective Studies / Liver Cirrhosis Type of study: Observational study / Prognostic study Limits: Aged / Humans / Male Language: English Journal: Clinical and Molecular Hepatology Year: 2016 Type: Article