Evaluation on clinical effect of sIgA combined with Jiawei Yuping Feng pulvis in treatment of upper respiratory infection in children / 中国生化药物杂志

ABSTRACT

Objective To investigate clinical effect of sIgA combined with Jiawei Yuping Feng pulvis in treatment of upper respiratory infection ( URI) in children.Methods 160 children in hospital diagnosed with URI were randomly divided into treatment group and control group.With basic treatment, the control group were treated with Jiawei Yuping Feng pulvis, twice per day, 3 g each time, orally; treatment group on the basis of control group, secretory IgA via nasal drip, 0.3-0.5 mg/( kg? d) , dividing into 6-8 times.The treatment course was 7 days.The total efficiency, improvement of symptoms and adverse reactions were observed and compared.Results The total effective rate of treatment group (96.25%) was significantly higher than control group (85%)(χ2 =5.96, P<0.05).After 7 days of treatment, WBC and NEUT% of treatment group decreased significantly compared with control group ( P <0.05 ) .The fever, sore throat and runny nose, cough and expectoration symptom remission time of treatment group were significantly shorter than control group (P<0.05).Adverse reactions of both groups were lower.Conclusion It is effective to treat URI in children using sIgA combined with Jiawei Yuping Feng pulvis therapy, and it has few adverse reactions.