Clinical observation of warfarin combined with lanatoside C in treatment of elderly patients with dilated cardiomyopathy / 中国生化药物杂志

ABSTRACT

Objective To study effect of warfarin combined with lanatoside C on heart function indexes, its curative efficacy in elderly patients with dilated cardiomyopathy, and search for a better therapy for elderly patients with dilated cardiomyopathy.Methods 192 cases of patients with dilated cardiomyopathy were randomly divided into control group and treatment group, 96 cases in each group.Patients in control group were treated with warfarin, and treatment group were given warfarin combined with lanatoside C.After treatment, clinical curative effect evaluation, left ventricular ejection fraction (LVEF), early filling rate/advanced rate (E/A), early peak flow velocity (EPFV), atrium peak flow velocity (APFV), and cardiac indexes related to cardiac volume left ventricular end systolic volume (LVESV), left ventricular end diastolic volume (LVEDV), left ventricular mass (LV), cardiothoracic ratio (CTR), and 6min walk test were observed and recorded in two groups.Results The total effective rate in treatment group (85.42%) was significantly higher than that of control group (68.75%, P<0.01).The LVEF, E/A, EPFV, APFV in two groups of patients were improved compared with those before treatment (P<0.01), and the improvement of the above indexes in treatment group were significantly better than those in control group (P<0.01).The LVESV, LVEDV, LV, and CTR were improved in two groups after treatment than before treatment (P<0.01), and the improvement of above indexes in treatment group were significantly better than control group after treatment(P<0.05).6min walking test results were improved in two groups after treatment than before treatment ( P<0.05 ) , and the treatment group was significantly better than control group (P<0.05).There were no significant differences between two groups in adverse reactions.Conclusion Warfarin combined with lanatoside C in the treatment of elderly patients with dilated cardiomyopathy is a safe and effective treatment method.