The expression of serum squamous cell carcinoma antigen in patients with common skin diseases / 医学研究生学报

ABSTRACT

Objective There is a significant increase of squamous cell carcinoma antigen ( SCCA) in patients with common skin diseases .The aim of this study was to investigate the difference expression of serum SCCA in patients with common skin diseases . Methods A total of 497 patients with 14 kinds of common skin diseases from the Department of Dermatology were recruited , and the serum SCCA was measured . Results The positive rates of SCCA in 116 patients with psoriasis and 37 patients with erythroderma were 90 .5% and 100%, respectively .The common skin diseases with positive rate of SCCA greater than 60% includes eczema (61.7%), generalized dermatitis (65.1%),pemphigus (61.1%), bullous pemphigoid (62.2%).The SCCA values in pustulosa (1.76 ±1.22 ng/mL) and arthropathica psoriasis (1.69 ±1.05 ng/mL) were decreased compared with pustular (2.86 ±1.46 ng/mL) and arthropathica psoriasis (3.56 ±1.84 ng/mL) (P<0.05). Conclusion The SCCA value may have a relationship with the increase of the performance of keratinization and desquamation in the skin diseases , and it could be used as a valuable indicator for the diagnosis and treatment in patients with cutaneous diseases .