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Transdermal Penetration Enhancement of Arginine Oligomer-chitosan on Tinidazole in vitro and in vivo / 中国药师
China Pharmacist ; (12): 707-711, 2015.
Article in Chinese | WPRIM | ID: wpr-464126
ABSTRACT

Objective:

To study the in vitro and in vivo transdermal enhancement of one kind of arginine oligomer-chitosan ( CS-R9).

Methods:

In vitro mouse skin as the barrier, Franz diffusion cells were used to study the transdermal property of tinidazole ( TNZ) solution in vitro enhanced by CS-R9 using TNZ solution as the negative control and TNZ solution with Azone as the positive control. The rats were randomly divided into three groups, TNZ solution group ( the negative group) , TNZ solution with Azone group (the positive group) and TNZ solution with CS-R9 group. At the predetermined time intervals, 0. 5 ml blood was withdrawn from the rats and TNZ concentration was detected by HPLC to evaluate the enhancement of CS-R9 on TNZ in vivo.

Results:

Compared with the negative group, CS-R9 had significant enhancement on TNZ trandermal penetration in vitro(P 0. 05). The in vivo results showed CS-R9 exhibited similar transdermal enhancement on TNZ as Azone at the same concentration (P>0. 05), and CS-R9 had sustalned-release property.

Conclusion:

CS-R9 has promising transdermal en-hancement on TNZ, which is valuable to be studied further.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article