Roles and Mechanisms of Advanced Glycation End Products in Diabetic Gastrointestinal Motility / 胃肠病学

ABSTRACT

Diabetes mellitus( DM)affects almost the whole digestive tract. Approximately 75% of the diabetic patients suffer from gastrointestinal motility disorders. The precise mechanism of diabetic gastrointestinal motility disorders is not fully clear. Its pathogenesis is considered to be multifactorial and related with autonomic neuropathy,smooth muscle myopathy and lesions of interstitial cells of Cajal. Advanced glycation end products( AGEs ) are derived from the nonenzymatic reaction of glucose with proteins,lipids or nucleic acids in vivo. Hyperglycemia in DM is a favourite for formation of AGEs, and excessive accumulation of AGEs contributes to the complications of DM such as diabetic nephropathy and diabetic vascular lesions. However,the correlation of AGEs with diabetic gastrointestinal motility disorders is seldom reported. In this review article,the roles and possible mechanisms of AGEs in diabetic gastrointestinal motility were summarized.