Optimization of Preparation Technology of Zhuqi Fugan Granules by Orthogonal ;Experiment / 中国中医药信息杂志

ABSTRACT

Objective To optimize the formative technology for Zhuqi Fugan Granules. Methods By using orthogonal experiment design, and setting parameters of granules as determination standards, concrete density, excipient types and dosage, and consentration of wetting agent were optimized to determine the optimal conditions. Results The optimal forming technology was as followsThe optimal ratio of starch to micrite cellulose was 3∶2;the optimal density of extration was 1.20;the ratio of concrete to excipient was 1∶1;the optimal concentration of wetting agent was 80% of ethyl alcohol. Zhuqi Fugan Granule enjoyed good mobility and with a critical relative humidity of 67%. Conclusion Parameters of Zhuqi Fugan Granules prepared by this method are satisfying, with stable properties and low moisture absorbtion. This preparation technology is simple and feasible.