Distribution and drug resistance of common pathogens in Xinjiang area / 国际检验医学杂志

ABSTRACT

Objective To investigate the distribution and drug resistance of common pathogens in Xinjiang ,aare so as to provide references for reasonable use of antibiotics .Methods The strains of common pathogens isolated from patients in the First Teaching Hospital of Xingjiang Medical University from 2012 to 2013 were collected ,and the drug susceptibility testing were performed by K‐B methods recommended by CLSI .Results Totally 18 374 strains were isolated ,among them 13 323 strains were gram negative and 5 051 strains were gram positive .Escherichia coli ,Klebsiella pneumoniae ,Staphylococcus aureus ,Acinetobacter baumannii and Pseudomonas aeruginosa occupied the top 5 .Most of strains were isolated from sputum (accounted for 36 .1% ) .Escherichia coli and Klebsiella pneumoniae showed high resistance rate to cefazolin sodium ,cefotaxime and quinolones .The detection rate of ESBLs pro‐ducing Escherichia coli and Klebsiella pneumoniae were 48 .4% and 41 .7% ,respectively .The resistance rate of Pseudomonas aerug‐inosa to commonly used antibiotics was 10 .0% ~20 .0% .Methicillin resistant staphylococcus aureus(MRSA) accounted for 44 .7%of all Staphylococcus aureus ,and no strains of Staphylococcus resistant to vancomycin ,teicoplanin and Linezolid were found .Conclu‐sion Gram negative bacteria are the most common strains isolated from clinical in this area ,and strains are mainly isolated from samples of respiratory tract and genitourinary tract ,and the situation of drug resistance is severe ,which indicate the clinicians should strengthen the monitoring of drug‐resistant bacteria and promote rational use of antimicrobial agents .