Association Study Between the rs4373814 Polymorphisms of Calcium Channel Gene and the Susceptibility of Essential Hypertension in Han Population at Northeastern Area of China / 中国循环杂志
Chinese Circulation Journal
;
(12): 661-664, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-465103
ABSTRACT
Objective:
To investigate the relationship between rs4373814 polymorphisms of calcium channel (CACNB2) gene and the susceptibility of essential hypertension (EH) occurrence in Han population at northeastern area of China.Methods:
A case-control study in Han population at northeastern of China was carried out and the research included 1998 participants as 2 groups EH group,n=1006 patients treated in our hospital, and Control group,n=992 subjects with normal blood pressure from physical examination. The rs4373814 polymorphisms were examined by Snapshot technique and the statistical analysis was performed by SPSS 19.0 software.Results:
The rs4373814 risk allele C frequency of CACNB2 gene was signiifcantly different between EH group and Control group,P=0.039, OR=1.068, 95% CI (1.004-1.137). Logistic regression analysis showed that with adjusted gender, age, BMI, smoking, drinking, in dominant model, the genotype rs4373814 carring CC + GC/GG obviously increased the risk of EH occurrence,P=0.037, OR=1.260, 95% CI (1.013-1.567).Conclusion:
The rs4373814 polymorphisms of CACNB2 gene are related to the susceptibility of EH occurrence in Han population at northeastern area of China.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Observational study
/
Risk factors
Language:
Chinese
Journal:
Chinese Circulation Journal
Year:
2015
Type:
Article
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