Application of Multimodal Analgesia in Lower Extremity Orthopedic Surgery for Patients with Cerebral Palsy following Spasm / 中国康复理论与实践

ABSTRACT

Objective To observe the application of multimodal analgesia (MA) in lower extremity orthopedic surgery (LEOS) for pa-tients with cerebral palsy (CP). Methods 100 CP patients following spasm undergoing LEOS under combined general anesthesia were ran-domly assigned into group C (n=50) and group M (n=50). In group M, the methods including a small dose of intravenous ketamine (0.25 mg/kg) 15 minutes before skin incision, 0.25%ropivacaine hydrochloride in surgical area with infiltration anesthesia just before skin incision, and an intravenous infusion of sufentanil (0.05μg/kg/h) combined with remifentanil (0.2μg/kg/min) were performed. In group C, the meth-ods mentioned above were not performed. The intravenous analgesia pump for single-use was prescribed for the patients in both groups. The postoperative analgesic effect (PAE) and side effects were observed. Results 4 dropped in group C. PAE in group M was significantly superi-or to that in group C (P0.05). Conclusion MA could increase PAE in LEOS for CP patients following spasm and the safety was not influenced.