Relationship between rs7903146-T/C polymorphism of TCF7L2 gene and gestational diabetes mellitus / 中国医师杂志
Journal of Chinese Physician
;
(12): 65-67, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-466002
ABSTRACT
Objective To investigate the relationship between rs7903146-T/C polymorphism of transcription factor7-like 2 gene (TCF7L2) gene and gestational diabetes mellitus in Han population of Liaoning province.Methods The rs7903146-T/C polymorphism was detected in 115 healthy Han controls and 113 patients with gestational diabetes mellitus by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results There were three genotypesCC,CT,and TT; and their frequencies in control group and patients were 95.65%/84.96%,4.35%/15.04%,and 0/0,respectively.The allele frequency T of rs7903146 in control group and the patients was 2.17% and 7.52%,respectively.There was statistical difference between two groups.Conclusions The rs7903146-T/C polymorphism of TCF7L2 might be associated with gestational diabetes mellitus in Liaoning Han population.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2015
Type:
Article
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