Poly (ADP-ribose) polymerase-1 and ischemic brain injury / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 946-949, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-466516
ABSTRACT
Poly (ADP-ribose) polymerase-1 (PARP-1) is a ribozyme that widely exists in the cukaryotic cells.It plays important roles in the maintenance of genomic stability and the regulation of gene transcription and other physiological processes.PARP-1 is overactivated after ischemic brain injury,and PARP-1 gene knockout mice or PARP-1 inhibitor can reduce brain injury in a variety of models of cerebral ischemia.Therefore,PARP-1 plays important roles in the pathophysiologic processes of ischemic brain injury.The investigation of the effect of PARP-1 in cerebral ischemia contributes to further understanding the pathophysiologic mechanism of stroke and finding a new therapeutic target.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2014
Type:
Article
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