Clinical characteristics and correlative factors analysis of ANCA-associated vasculitis with interstitial lung disease / 中华风湿病学杂志

ABSTRACT

Objective To understand the clinical characteristics and correlative factors of ANCA-associated systemic vasculitis with interstitial lung disease.Methods Seventy-five AASV patients in Shanghai Renji Hospital from January 2010 to June 2013 were selected.The clinical data of those cases with interstitial lung disease were analyzed retrospectively and logistic regression model was applied to analyze the correlative factors.Results Of the 75 AASV patients,52％ were male,48％ were female,and the average age was (56±19) years.Forty-four cases were defined as interstitial lung disease.Among patients with interstitial lung dis-ease,31 (70％) cases were chronic onset,32(72％) cases had pulmonary infection and 8 (18％) cases died.The main chnical manifestations were dry cough,shortness of breath after labour and fever,the proportion was 68％,36％ and 50％ respectively.Irregular linear shadow was the main imagine changes,the rate was 55％.Pulmonary function changes varied in degrees with diffusion capacity reduction.Multivariate logistic regres-sion analysis showed that those who were older than 60 years (OR=3.44,95％CI1.05-11.28),positive for MPO-ANCA (OR=3.7,95％CI1.10-12.65) and Birmingham vasculitis activitv score higher than15 (OR=3.67,95％CI1.21-11.15) were more likely to have interstitial lung disease.Conclusion Interstitial lung disease is one of the common pulmonary damages of ANCA-associated systemic vasculitis and it will lead to death because of respiratory failure or secondary pulmonary infection.Those who are elders,with positive MPO-ANCA,and with active disease are at high risk for interstitial lung disease among AASV patients.The results of this study sugest that clinicians should pay more attention to patients with these high risk factors.