Recent developments in pathogenesis of Hirschsprung's disease / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
; (24): 1761-1763, 2014.
Article
in Zh
| WPRIM
| ID: wpr-466749
Responsible library:
WPRO
ABSTRACT
Hirschsprung's disease (HD) is a conginental disorder of enteric nervous system (ENS) and is associated with the abnormal migration of gut neural cerst cell (GNCC).Recent studies showed that the regulation of this migration is a complex gene network.By the development of epigenetic and stem cells,this network is becoming much more clear.Transplantation of the modified gut neural crest stem cells/gut neural crest precursors(GNCSC/GNCP) acquired from the HD bowl is becoming the potential therapy of HD.This paper summerizes the recent advances and is to promote better understanding the pathogenesis of HD.
Full text:
1
Index:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
Chinese Journal of Applied Clinical Pediatrics
Year:
2014
Type:
Article