Physeal Defect Model of Rabbit's Tibia : Conventional Curettage vs Box Osteotome Method / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 146-152, 2006.
Article
in English
| WPRIM
| ID: wpr-46675
ABSTRACT
PURPOSE:
In many previous animal studies on cell therapy to the physeal defect, the defect was made by curetting the physeal cartilage with a scalpel, a syringe needle, or a curette. Authors questioned the validity of this method because it may be accompanied by the risk of incomplete removal of physis. MATERIALS ANDMETHODS:
Eight-week-old New Zealand White rabbits were used. In the scalpel group(n=32), a physeal defect was made on the medial half of the bilateral proximal tibiae by the conventional curettage method as previously described. In the box osteotome group (n=16), physis and adjoining eiphyseal and metphyseal bone segments were removed with a box osteotome and a motorized burr.RESULTS:
Histological examination showed that, in the scalpel group, incomplete removal of physeal cartilage was observed in 14 of 38 (37%) tibiae sacrificed between Day 1 and 7, while all of the 20 (100%) in the box osteotome group showed complete removal of physeal cartilage.CONCLUSION:
The results show the high risk of incomplete removal of physeal cartilage with the conventional curettage method. We believe that our method using a box osteotome and a motorized burr is better in terms of ease and validity in creating physeal defect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Syringes
/
Tibia
/
Cartilage
/
Curettage
/
Cell- and Tissue-Based Therapy
/
Needles
Limits:
Animals
Language:
English
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2006
Type:
Article
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