Research progress of epigenetic regulation of histone methyltransferase EZH2 in hematologic neoplasms / 白血病·淋巴瘤

ABSTRACT

The histone H3 lysine 27 methyltransferase EZH2 takes part in heterochromatin formation and gene transcription regulation.EZH2 is frequently over-expressed in a wide variety of cancerous tissue types,which reveals it to be oncogenic.However,in myeloid malignancies,EZH2 could act as a tumor suppressor.This paper mainly reviews the structure and function of EZH2 and its effect on hematologic neoplasms.Taking EZH2 as target will provide systematic understanding for the treatment of hematologic neoplasms.