Your browser doesn't support javascript.
loading
Application of quantitative of preferentially expressed antigen of melanoma gene expression in monitoring acute myeloid leukemia and minimal residual disease / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma ; (12): 115-117, 2015.
Article in Zh | WPRIM | ID: wpr-466929
Responsible library: WPRO
ABSTRACT
Objective To investigate the expression of the preferentially expressed antigen of melanoma (PRAME) gene in acute myeloid leukemia (AML),and to evaluate its applicability in monitoring minimal residual disease (MRD).Methods Bone marrow specimens were collected from 63 cases of de-novo AML,while 34 samples from 11 patients were tracked for 28 months.The level of PRAME mRNA was measured by real time RT-PCR.Results The PRAME gene expressed in 52.4 % (33/63) of de-novo patients,and the positive rate was highest in M3 than that in other subtypes of AML.The expression of PRAME became negative after treatment and increased in the following months before morphology relapse.Conclusion The PRAME gene is highly expressed in AML and could be a useful marker to monitor MRD.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Leukemia & Lymphoma Year: 2015 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Leukemia & Lymphoma Year: 2015 Type: Article