Meta-analysis for correlation between multiple lung lobe lesions and prognostic influence on acquired pneumonia in hospitalized elderly patients / 中南大学学报(医学版)

ABSTRACT

Objective: To explore the correlation regarding the prognostic influence between multiple lung lobe lesions and acquired pneumonia in hospitalized elderly patients by a Meta-analysis. Methods: We collected all studies which investigated the correlation regarding the prognostic effect between multiple lung lobe lesions and acquired pneumonia by searching China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, Chinese Biological Medical Literature Database, PubMed, and EMBase in accordance with the inclusion and exclusion criteria. hTe retrieval limit time of searches was from databases establishment to July 2014. hTe Meta-analysis was performed by using RevMan5.2 sotfware. We calculated the odds ratio (OR) and 95% conifdence interval (95% CI) by using heterogeneous tests.Publication bias was assessed by Egger’s test and funnel plot, and the sensitivity was analyzed. Results: Ten studies involving 1 836 patients were ifnally included, with 487 cases (the dead group) and 1 349 controls (the survival group). The Meta-analysis demonstrated that multiple lung lobe lesions was highly correlated with the prognosis for the aged acquired pneumonia (OR=3.22, 95% CI 1.84 to 5.63). Conclusion: Multiple lung lobe lesions increase the risk of death in the prognosis of the aged patients with acquired pneumonia.