The clinical observation of different sequences of intravenous administration on sufentanyl-induced cough / 中国基层医药

ABSTRACT

Objective To evaluate the effects of different sequences of intravenous administration on sufenta-nyl-induced cough during induction of general anesthesia.Methods One hundred patients,aged 20 ~60 years,weig-hing 45 ~82 kg,ASA Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were equally randomized to two groups by using a random number tablesufentanyl-propofol group(group SP)and propofol-sufentanyl group(group PS).In group SP,sufentanyl 0.4μg/kg was injected intravenously over 5s,and then propofol 2mg/kg was injected intravenously.In group PS,propofol 2mg/kg was injected intravenously,and then sufentanyl 0.4μg/kg was injected intravenously over 5s.The occurrence,intensity and the time of cough were recorded within 1 min after sufentanyl injection.Results The incidence of cough was 38%(19 /50)in group SP which was significantly higher than the 12%(6 /50)in group PS(χ2 =9.013,P 0.05).Conclusion Administration in the propofol-sufentanyl sequence can effectively reduce the occurrence of sufentanyl-induced cough as compared with that in the sufentanyl-propofol sequence during induction of general anesthesia.