The Role of Resectional Surgery for the Treatment of Localized Multi-drug Resistant Pulmonary Tuberculosis / 결핵
Tuberculosis and Respiratory Diseases
;
: 676-683, 2000.
Article
in Korean
| WPRIM
| ID: wpr-46731
ABSTRACT
BACKGROUND:
Surgery may have a role when medical treatment alone is not successful in patients with multi-drug resistant (MDR) pulmonary tuberculosis (PTB). To document the role of resection in MDR PTB, we analyzed 4 years of our experience.METHODS:
A retrospective review was performed on thirteen patients that underwent pulmonary resection for MDR PTB between May 1996 and February 2000. All patients had organisms resistant to many of the first-line drugs including isoniazid (INH) and rifampicin (RFP).RESULTS:
The thirteen patients were 37.5±12.4 years old (mean±S.D.)(MF=58), and their sputum was culture positive even with adequate medication for prolonged periods (109.7±132.0 months), resistant to 2-8 drugs including isoniazid and rifampin. All patients had localized lesion(s) and most (92.3%) had cavities. At least 3 sensitive anti-TB medications were started before surgery in all patients according to the drug sensitivity test. The preoperative FE1 was 2.37±0.83 L. Lobectomy was performed in 11 patients and pleuropneumonectomy in two. Postoperative mortality did not occur, but pneumonia occurred as a complication in one (7.7%). After 41.5±58.9 days (range 1~150 days) follow up, negative conversion of sputum culture was achieved in all patients within 5 months. Only one patient (7.7%) recurred 32 months after lung resection.CONCLUSION:
When medical treatment alone is not successful, surgical resection can be a good treatment option in patients with localized MDR PTB.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Rifampin
/
Sputum
/
Tuberculosis, Pulmonary
/
Retrospective Studies
/
Follow-Up Studies
/
Mortality
/
Isoniazid
/
Lung
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2000
Type:
Article
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