Effect of gliclazide on the proliferation and differentiation in mouse osteoblastic-like cells MC3T3-E1 / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 535-537, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-467484
ABSTRACT
[Summary] To investigate the effect of gliclazide on the proliferation and differentiation in MC3T3-E1 cells exposed to normal glucose concentration by applying CCK-8 and RT-PCR. Gliclazide improved the proliferation and stimulated COL-I, OPN and Runx2 mRNA expression in MC3T3-E1 cells, the best concentration of gliclazide was 20μmol/ L, the expression of COL-1 and OPN mRNA had a significant positive correlation with Runx2 binding activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2015
Type:
Article
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