Application of pidotimod oral solution in children with recurrent respiratory tract infections / 中国医师进修杂志

ABSTRACT

Objective To study the application value of pidotimod oral solution in children with recurrent respiratory tract infections (RRTIs).Methods Ninety-two children with RRTIs were divided into observation group and control group by random digits table method with 46 cases each.The children in control group were given conventional treatment.The children in observation group were added pidotimod oral solution on the basis of conventional treatment.The serum immunoglobulin (lg) G,IgM,IgA,and peripheral blood T lymphocyte subgroup (CD3+,CD4+,CD8+) before and after treatment,improvement of clinical symptoms and signs,the recurrence time of respiratory tract infections during 1 year after treatment,and untoward reaction were compared between 2 groups.Results The IgG,IgM and IgA levels after treatment in observation group were significantly higher than those in control group(9.98 ± 2.26) g/L vs.(8.49 ± 2.23) g/L,(1.27 ± 0.28) g/L vs.(1.10 ± 0.21) g/L,(0.95 ± 0.27) g/L vs.(0.72 ± 0.23) g/L,and there were statistical differences (P ＜ 0.05).The CD3+ and CD4+ levels after treatment in observation group were significantly higher than those in control group0.706 ± 0.087 vs.0.630 ± 0.069,0.456 ± 0.047 vs.0.348 ± 0.034,and CD8+ level was significantly lower than that in control group0.177 ± 0.046 vs.0.212 ± 0.041,and there were statistical differences (P ＜ 0.05).The time to defervesce,disappearing time of coughing,disappearing time of tonsil swelling and disappearing time of lung rale in observation group were significantly shorter than those in controlgroup(2.82±0.71)d vs.(3.86± 1.11) d,(4.26± 1.54)d vs.(5.69± 1.82) d,(3.12± 1.02) d vs.(4.67 ± 1.40) d,(3.35 ± 1.58) d vs.(4.75 ± 1.58) d,and there were statistical differences (P ＜ 0.05).The recurrence time of respiratory tract infections during 1 year after treatment in observation group was significantly lower than that in control group(5.08 ± 1.61) times vs.(7.25 ± 1.68) times,and there was statistical difference (P＜ 0.05).The untoward reaction was not found in the 2 groups.Conclusion Pidotimod oral solution has the prevention and treatment effect in children with RRTIs.