Effect of berberine on D-dimer, fibrinogen and interleukin-6 in peripheral blood of ovarian cancer patients / 中国生化药物杂志

ABSTRACT

Objective To analyse the effect of berberine on D-dimer, fibrinogen (FIB) and interleukin-6(IL-6) in peripheral blood of ovarian cancer patients.Methods 130 cases selected from the hospital were diagnosed as unilateral ovarian cancer, treated by surgery and chemotherapy.The patients were divided into control group (25 cases) and experimental group (105 cases), and the experimental group were randomly divided into A, B, C three groups, 35 cases in each group.The experimental group received berberine hydrochloride tablets, orally, three times a day, on the basis of conventional chemotherapy.The experimental groups were divided into three subgroups according to the dosage A group 0.3 g, B group 0.2 g, C group0.1 g, 35 cases in each group, continuously treated for 2 weeks.The levels of D-dimer, FIB and IL-6 and quality of life score were detected before and after treatment.Results After treatment, D-dimer level in each subgroup of experimental group was lower than that in control group, respectively, and A groupcontrol group, respectively, and A group IL-6 levels in A and B group were lower than that in control group, respectively, but there was no significant difference between C group and control group, and A and B group quality of life scores in A and B group were lower than that in control group (P<0.05), while there was no significant difference between C group and control group, and A group Berberine could reduce the levels of D-dimer, FIB and IL-6 in peripheral blood of ovarian cancer patients and improve the quality of life, with the dose-dependence.