NO-cGMP-PKG pathway and cardiovascular disease / 国际儿科学杂志

ABSTRACT

Nitric oxide ( NO ) , cyclic guanosine 3′, 5′-monophosphate ( cGMP ) and cGMP-dependent protein kinase( PKG) play an important role in a variety of tissue cells. This paper reviews the related literatures about the NO-cGMP-PKG pathway and the cardiovascular diseases since the close relationship between them by summarizing the founction of the NO-cGMP-PKG pathway and the affection on the cardiovascular diseases by the NO-cGMP-PKG pathway,aiming to find a new research direction of the pathogenesis of cardiovascular disea-ses.