Pathogens and drug resistance analysis in stroke patients with hospital-acquired pneumonia / 中国医师进修杂志

ABSTRACT

Objective To analyze the distribution and drug resistance of pathogens causing hospital-acquired pneumonia (HAP) in stroke patients,and provide references for proper clinical application of antibiotics.Methods A retrospective investigation was performed to analyze the pathogens and the drug resistance of 143 stroke patients with HAP.Results Among 168 strains of isolated pathogens,the Gram-negative bacteria accounted for 61.90％ (104/168),including Klebsiella pneumoniae,Pseudomonas aeruginosa,Escherichia coli,Acinetobacter baumannii,Enterobacter cloacae and so on.Gram-positive bacteria accounted for 25.60％ (43/168).Staphylococcus aureus ranked the first,followed by Coagulase negative staphylococcus and Enterococcus faecalis.Fungi accounted for 12.50％(21/168),mainly including Candida albicans.They had varying degrees of resistance to commonly used antibiotics.Conclusions Gram-negative bacteria is predominant in stroke patients with HAP.Drug resistance is very serious,and the antibiotics should be selected in clinic according to the result of drug susceptibility test.