Risk Factors for Relapse in Patients with Inflammatory Bowel Disease:Analysis of 479 Clinical Cases / 胃肠病学
Chinese Journal of Gastroenterology
;
(12): 411-416, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-468373
ABSTRACT
Background:
Inflammatory bowel disease(IBD)is a chronic,non-specific,relapsing inflammatory bowel disorder. Prediction of prognosis and relapse is of great importance for disease control.Aims:
To analyze the characteristics and related factors for relapse in IBD patients.Methods:
Four hundred and seventy-nine hospitalized patients diagnosed as ulcerative colitis(UC,n = 301)or Crohn’s disease( CD,n = 178)from Jan. 2004 to Jun. 2014 were enrolled and divided into relapse group and non-relapse group. The clinical characteristics were collected and univariate and multivariate analysis were performed to identify the influencing factors for relapse.Results:
The relapse rates for UC and CD were 52. 49% and 77. 53% ,respectively. In stepwise Logistic regression analysis,younger onset age( < 40 years old,OR =0. 825,95% CI0. 777-0. 876,P = 0. 000),longer disease duration(OR = 1. 186,95% CI1. 089-1. 291,P = 0. 000) and extensive colitis(OR = 16. 993,95% CI2. 670-108. 170,P = 0. 003)were independent risk factors for relapse of UC,while younger onset age( < 40 years old,OR = 0. 944,95% CI0. 915-0. 974,P = 0. 000)and poor medication adherence(OR = 31. 074,95% CI10. 456-92. 343,P = 0. 000)were independent risk factors for relapse of CD.Conclusions:
Patients at high risk for relapse of IBD can be identified by referring to the related risk factors. Early identification and intervention,persistence for maintenance therapy and improving medication adherence by health education may reduce the clinical relapse of IBD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Gastroenterology
Year:
2015
Type:
Article
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