Long noncoding RNAs in gene expression control / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1196-1202, 2014.
Article
in Zh
| WPRIM
| ID: wpr-468420
Responsible library:
WPRO
ABSTRACT
Studies have shown that most of the sequence in the mammalian genome is transcribed into long noncoding RNAs (lncRNAs). Their crucial roles in gene regulation are becoming a hotspot in current biomedical research. LncRNAs can control gene activities through multiple mechanisms such as: 1) direct or indirect regulation of gene expression via cis-/trans-action or function as protein baits in the nucleus; 2) affecting the stability and the translational process of mRNA; 3) functioning as competitors to regulation of microRNA; 4) binding to transcription factors. Recent studies have highlighted the significance of lncRNAs in development and diseases, and their potentials in future clinical application.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article