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Relationship between vitmin D receptor rs2228570 polymorphism and susceptibility to gout in Chinese Han male population / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12): 316-319, 2015.
Article in Chinese | WPRIM | ID: wpr-468513
ABSTRACT
Objective To explore gene polymorphism of G/A genotype of Fok Ⅰ rs2228570 (G/A) of vitamin D receptor (VDR) gene in Han male population of Chinese coastal area,and thus to investigate the relationship between the gene polymorphism of VDR and gout.Methods Altogether 504 gout patients and 523 healthy controls were enrolled.The possible association between the polymorphism of VDR rs2228570 and gout in Chinese coastal area was investigated and genotype frequencies and allelic frequencies were calculated by realtime PCR with Taqman(R)probe method.Hardy-Weinberg was used to verify the representativeness of the sample.Comparison between the groups were performed withx2 test and t-test.Results The frequencies of GG,AG,and AA genotypes were 32.1%,50.0%,and 17.9%,respectively among gout patients,while they were 27.9%,50.5%,and 21.6% respectively among the controls.There was no statistically significant difference in VDR rs2228570 genotype frequencies between gout patients and controls(x2 =3.366,P>0.05).The allele frequencies of G and A in gout cases were different from those in the controls(57.1%,42.9%;53.2%,46.8%;x2 =3.300,P>0.05).Conclusions Results of the present study suggest that the G/A genotype of VDR Fok Ⅰ rs2228570 of the VDR gene is not associated with gout in male population of Chinese coastal area.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 2015 Type: Article