A multicenter study of correlation between peripheral lymphocyte counts and CD4+ T cell counts in HIV/AIDS patients / 中华内科杂志
Chinese Journal of Internal Medicine
;
(12): 118-121, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-468596
ABSTRACT
Objective To evaluate the accuracy of lymphocyte count as a surrogate for CD4+T cell count in treatment-na(i)ve HIV-infected adults.Methods A total of 2 013 HIV-infected patients were screened at 23 sites in China.CD4+ T cell counts were measured by flow cytometry.Correlation between CD4+ T cell count and peripheral lymphocyte count were analyzed by spearman coefficient.AUCRoc were used to evaluate the performance of lymphocyte count as a surrogate for CD4+ T cell count.Results The lymphocyte count and CD4+T cell count of these 2 013 patients were (1 600±670) × 106/L and (244 ± 148) × 106/L respectively.CDa+ T cell count were positively correlated with lymphocyte count(r =0.482,P <0.000 1).AUCROC of lymphocyte count as a surrogate for CD4+ T cell counts of < 100 × 106/L,<200 × 106/L and < 350 × 106/L were 0.790 (95% CI 0.761-0.818,P < 0.000 1),0.733 (95% CI 0.710-0.755,P < 0.000 1) and 0.732 (95% CI 0.706-0.758,P < 0.000 1) respectively.Conclusion Lymphocyte count could be considerad as a potential surrogate marker for CD4+ T cell count in HIV/AIDS patients not having access to T cell subset test by flowcytometry.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Internal Medicine
Year:
2015
Type:
Article
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