The association between angiogenin gene variations and familial amyotrophic lateral sclerosis in Chinese Han patients / 中华内科杂志
Chinese Journal of Internal Medicine
;
(12): 122-124, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-468597
ABSTRACT
Objective To investigate effect of genetic variants in angiogenin (ANG) on the susceptibility of familial amyotrophic lateral sclerosis (FALS) in Han Chinese.Methods Thirty-one FALS families from 2009 to 2012 were collected and ANG gene was screened in the probands using PCR and direct sequencing.Results All 31 ALS families were autosomal dominant inheritance.No mutations and single nucleotide polymorphism were detectable in ANG gene in the 31 probands.Conclusion Our study suggests that ANG gene variations may be rare in Chinese Han FALS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Internal Medicine
Year:
2015
Type:
Article
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