Inhibitory effect of 5-aminolevulinic acid photodynamic therapy on human papillomavirus replication in condyloma acuminatum lesions / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12): 739-741, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-468652
ABSTRACT
Objective To detect the changes in DNA loads of human papillomavirus (HPV) type 6/11 in lesions of patients with condyloma accuminatum (CA) before and after 5-aminolevulinic acid photodynamic therapy (ALA-PDT).Methods After removal of warts by electrocautery,HPV6/11-positive patients with CA were divided into two groupstreatment group (32 cases) receiving two sessions of ALA-PDT with intervals of 7-10 days,and control group (29 cases) remaining untreated.Exfoliated cells were collected from the lesional sites of these patients before and 3 months after the first session of ALA-PDT,and fluorescence-based quantitative PCR was conducted to estimate the DNA loads of HPV 6/11 in these cells.Results Three months after the first session of ALA-PDT,89.7% (26/29) of the patients in the treatment group and 68.4% (13/19) in the control group became HPV DNA negative,with significant differences between the treatment group and control group in the DNA loads of HPV ((1.70 ± 7.86) × 105 vs.(1.27 ± 2.21) × 106 copies/ml,P < 0.05).Conclusion ALA-PDT can reduce HPV DNA loads in lesions of CA in patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Dermatology
Year:
2014
Type:
Article
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