Correlation between macular structural changes and functional outcomes in idiopathic macular epiretinal membranes / 中华全科医师杂志

ABSTRACT

Objective To investigate the correlation between macular structural changes and functional outcomes in idiopathic macular epiretinal membranes (IMEM).Methods Clinical data of 85 patients with monocular IMEM admitted from April 2013 to April 2014 were retrospectively analyzed.The diseased eyes(85 eyes)were studied as observation group and the normal eyes (85 eyes)served as control group.The results of routine eye examinations,optical coherence tomography (OCT) and multifocal electroretinography (mfERG) were compared between observation and control groups.Results The preoperative best corrected visual acuity (BCVA) in observation group was lower than that in control group (0.55-± 0.17 vs.0.92 ± 0.14,P ＜ 0.05);the eyes with BCVA ＜ 0.1 in observation group were more than those in control group (P ＜ 0.05).The central retinal thickness (CRT) of observation group was higher than that of control group[(322.1 ±54.3) μm vs.(210.3 ±47.5) μm,t =14.29,P ＜0.05].The average response density of N1 wave and P1 wave in observation group were (36.7 ± 19.7) and (95.2 ±24.0) nV/ deg2,which were lower than those in control group [(42.9 ± 16.3) and (134.8 ± 20.1) nV/deg2;t =-2.23 and-11.66,respectively,P ＜0.05].The latent period of N1 wave and P1 wave in observation group were (22.0 ±4.1) and (39.5 ± 4.7) ms,which were lower than those in control group [(18.7 ± 3.0) and (38.0 ± 3.2) ms;t =5.99 and 2.43,respectively,all P ＜ 0.05].The CRT in observation group was not correlated with average response density of macular center N1,P1 wave and latent period (r =-0.23,-0.35,0.06,-0.04,all P ＞ 0.05).BCVA in observation group was negatively correlated with CRT(r =-2.16,P ＜ 0.05).Conclusions The central retinal thickness is negatively correlated with the best corrected visual acuity,but not correlated with center mfERG in patients with IMEM.