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Influence of pre-existing antiplatelet treatment on acute ischemic stroke patients receiving intravenous thrombolysis: a systematic review / 中华神经科杂志
Chinese Journal of Neurology ; (12): 65-70, 2015.
Article in Chinese | WPRIM | ID: wpr-469019
Responsible library: WPRO
ABSTRACT
Objective To evaluate the influence of antiplatelet therapy prior to intravenous thrombolysis (IVT) on acute ischemic stroke (AIS) patients receiving IVT with recombinant tissue type plasminogen activator (rt-PA).Methods Researches about the safety of pre-existing antiplatelet treatment on AIS patients undergoing rt-PA IVT published before 31st December 2013 were retrieved based on internet databases.A meta-analysis of included clinical trials was performed by RevMan 5.2 and Stata 12.0 software.Simultaneously,funnel plot and Egger's test were used to evaluate the publication bias.Results A total of 10 papers were included.Eight researches based meta-analysis showed that pre-existing antiplatelet therapy increased the risk of symptomatic intracranial hemorrhage (SICH ; OR =1.67,95% CI 1.44-1.93,P < 0.01),6 researches based analysis suggested pre-existing antiplatelet therapy increased the risk of any intracranial hemorrhage (ICH ; OR =1.23,95% CI 1.04-1.47,P < 0.05) and 3 trials based analysis indicated the functional independence of patients receiving antiplatelet treatment was a bit worse than control group (OR =0.86,95% CI0.80-0.93,P <0.01).Funnel plots and Egger' s test showed that there was no significant publication bias (P > 0.05).Conclusions Antiplatelet therapy might increase the risk of post thrombolysis SICH and ICH,and their 3-month function independence is not so satisfied as those who had no antiplatelet agents before IVT.However,this review has limitations and the above results should be validated in future large prospective clinical studies.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Systematic reviews Language: Chinese Journal: Chinese Journal of Neurology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Systematic reviews Language: Chinese Journal: Chinese Journal of Neurology Year: 2015 Type: Article