MELAS Syndrome Presenting as Occipital Brain Infarct: Case Report / 대한뇌혈관외과학회지
Korean Journal of Cerebrovascular Surgery
;
: 329-332, 2005.
Article
in English
| WPRIM
| ID: wpr-46937
ABSTRACT
MELAS syndrome is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. A 14-year-old male presented with symptoms that resemble stroke including headache, seizure, visual disturbance and slight left hemiparesis. Laboratory investigation showed elevated lactate level in the blood. Brain computed tomography and magnetic resonance image revealed acute infarction in the right occipitoparietal lobe, which was not restricted to a specific vascular territory. Magnetic resonance spectroscopy showed decreased N-acetyl aspartate and increased lactate level in the affected lobe. A molecular genetic analysis identified A3243G point mutation in the peripheral blood leukocytes and confirmed MELAS syndrome. We describe clinical, radiological and molecular genetic findings in the patient with MELAS syndrome presenting occipital brain infarct.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paresis
/
Seizures
/
Acidosis, Lactic
/
Brain
/
Magnetic Resonance Spectroscopy
/
Point Mutation
/
Mitochondrial Myopathies
/
MELAS Syndrome
/
Aspartic Acid
/
Lactic Acid
Limits:
Adolescent
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Cerebrovascular Surgery
Year:
2005
Type:
Article
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