The role of microRNA and lncRNA in pathophysiology of depressive disorder / 中华行为医学与脑科学杂志

ABSTRACT

Objective microRNA (miRNA) are a class of small molecule non-coding single-stranded RNA,and about 22 nucleotides (nt);lncRNA is a class of non-coding RNA long chain that longer than 200 nt,both of miRNA and lncRNA can regulate many kinds of genes' expression under different levels.This paper reviewed relationship of miRNA/lncRNAexpression level and depressive disorder,and to explore theirpredictive effects of antidepressantpharmacodynamics.Methods By retrieving literature in database of PubMed,ScienceDirect in February,March 2015 using microRNA,lncRNA,depressive disorder,antidepressants,biological markers as searching words and (depressive disorder OR antidepressant) and all fieldmiRNA/lncRNA as index strategy,based on literature retrieving,we acquired 87 articles and totally enrolled 50 close related articles as reviewing materials by literature screening.Results Existing studies suggested that miRNA and lncRNA may be involved in pathophysiology of depression,and miRNA may play a key role in antidepressant treatment.miRNA or lncRNA as biomarkers may be associated with depression.Conclusion Researches on miRNA or lncRNA shed light on pathological mechanism of depressive disorder and antidepressantpharmacodynamics.miRNAcan function in synaptic plasticity,sensitivity of stress reaction,production of neuron and brain-derived neurotropic factor,recovery of neural function after antidepressant treatment,while lncRNA has regulatory effects on chromosome remodeling,histone modification,Transcriptioninterference andactivation.