Expression and prognostic significance of interleukin-36α in colorectal cancers / 中国医师杂志
Journal of Chinese Physician
;
(12): 652-657, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-469439
ABSTRACT
Objective To investigate the expression and prognostic significance of Interleukin-36α (IL-36α) in colorectal cancer.Methods The expression of IL-36α was tested by immunohistochemical staining in 329 cases of colorectal cancer.According to the intensity and the proportion of positive tumor cells,all the patients were divided into IL-36α low and high expression groups.The clinicopathological factors and prognosis of patients between IL-36α low high expression groups were compared.Results Significant differences were observed in the number of patients in tumor differentiation and pM classification between patients in the IL-36α low and high expression groups (P < 0.05).The 5-year overall and tumorfree survival rates of patients were 79.3% and 77.2% in IL-36α low expression group,and 66.3% and 65.3% in IL-36α high expression group (P <0.05).COX proportional hazard regression model revealed that high expression of IL-36α was associated with short overall survival time and tumor-free survival time of colorectal cancer patients (P < 0.05).Multivariate analysis identified IL-36α expression in colorectal cancer as an independent prognosticator (P < 0.05).Conclusions High expression of IL-36α was correlated with tumor differentiation and pM classification of colorectal cancers,and it is an independent predictor of poor survival for patients with colorectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2015
Type:
Article
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