D-dimer levels of venous thrombosis in patients with the diagnosis of critical value of different ages / 中国医师杂志

ABSTRACT

Objective To compare plasma D-dimmer (D-D) levels of hospitalized patients and healthy controls,and to investigate D-D level changes in different age groups and receiver operating characteristic (ROC) curve analysis were used to analyze the clinical value of diagnosis of venous thromboembolism (VTE) by plasma D-dimer in different ages.Methods Totally 5798 healthy cases and 3756 cases of hospitalized patients were used for this study.Blood samples were collected and plasma D-dimer levels were analyzed.Results No significant difference was found in D-D level between the 50-year old hospitalized patients and healthy controls.D-D level of more than 50-year-old patient groups studied were significantly higher.D-D level was positively related to occurrence of VTE rate (r =0.9189,P ＜0.05).The sensitivity and specificity of D-D diagnosis of VTE in 50-year-old hospitalized patients were the highest,with the increase of age,the sensitivity and specificity of D-D diagnosis of VTE were decreased.Conclusions Plasma D-dimer levels were increased with age,The sensitivity of D-dimer was significantly decreased in the diagnosis of VTE of the elderly.The comprehensive indices should be used in the diagnosis of VTE.