Clinical significance of serum triglyceride and D-dimer in the early diagnosis of fat embolism syndrome after fracture / 中国综合临床

ABSTRACT

Objective To investigate the clinic significance of blood lipid and D-dimer in the early diagnosis of fat embolism syndrome (FES) after fracture.Methods Forty-nine cases of fracture complicated with fat embolism syndrome patients and 50 patients with fracture at the same time were selected as our subjects.The levels of serum triglyceride (TG) and D-dimer level were detected.Results Among the FES patients,61.2％ (30/49) were hemoglobin decline,followed by 57.1％ (28/49) with hypoxemia,51.0％ (25/49) with mucous membrane bleeding point,16.3 ％ (8/49) with pulmonary symptoms and 20.4％ (10/49) temperature ＞38℃.The levels of TG level and D-dimer in FES patients were (2.57 ± 0.84) mmol/L and (1758.5 ± 144.2) μg/L,significantly higher than patients without FES ((1.16 ± 0.34) mmol/L,(562.4 ±76.8) μg/L;P =0.000).ROC curve showed that the area under the curve(AUC) of TG in the diagnosis of FES was 68.3％,and the cut-off value was 2.04 mmol/L,with the sensitivity of 66.7％ and the specificity of 63.5％.The AUC of D-dimer was 67.4％,and the cut-off was 1 045.7 μg/L,with the sensitivity of 66.7％ and the specificity of 61.5％.Conclusion There is an important diagnostic value of serum TG and D-dimer in predicting FES after long and pelvic fracture,which can be used as a clinical powerful auxiliary examination in the diagnosis of FES.There is important clinical significance to improve the cure rate and reduce the death of FES.